The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
Isao I Oishi,
Hiroaki H Suzuki,
Nobuyuki N Onishi,
Ritsuko R Takada,
Shuichi S Kani,
Bisei B Ohkawara,
Ikue I Koshida,
Kentaro K Suzuki,
General G Yamada,
Georg C GC Schwabe,
Stefan S Mundlos,
Hiroshi H Shibuya,
Shinji S Takada and
Yasuhiro Y Minami
Genes Cells 8(7):645-54 (2003)
PMID 12839624
Ror2 is an orphan receptor, belonging to the Ror family of receptor tyrosine kinases. Although Ror2 has been shown to play crucial roles in developmental morphogenesis, the precise signalling events that Ror2 mediates remain elusive. Since Ror2 possesses an extracellular cysteine-rich domain (CRD) that resembles the Wnt-binding sites of the Frizzled (Fz) proteins, it is conceivable that Ror2 interacts with members of the Wnt family.
DOI: 10.1046/j.1365-2443.2003.00662.x
Version: za2963e q8zac q8zb3 q8zcd q8zd0 q8zeb q8zf4 q8zgb
