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Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.

R B RB Gearry, M L ML Barclay, M J MJ Burt, J A JA Collett, B A BA Chapman, R L RL Roberts, and M A MA Kennedy

Aliment Pharmacol Ther 18(4):395-400 (2003) PMID 12940924

Azathioprine and mercaptopurine (MP) are well established treatments for inflammatory bowel disease but they have severe adverse effects that prevent their use in some patients. The likelihood and type of adverse effect may relate to thiopurine methyltransferase (TPMT) enzyme activity and genotype.

DOI: 10.1046/j.1365-2036.2003.01690.x
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