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Bacillus subtilis and its relatives: molecular biological and industrial workhorses.

C R CR Harwood

Trends Biotechnol 10(7):247-56 (1992) PMID 1368322

The non-pathogenic bacterium Bacillus subtilis, since its first reported genetic transformation in 1959, has become a model system for the study of many aspects of the biochemistry, genetics and physiology of Gram-positive bacteria, and particularly of sporulation and associated metabolism. Extensive knowledge of the molecular biology of B. subtilis has led to the recent development of this bacterium as a host for the industrial production of heterologous proteins. Although difficulties have been encountered, these are being systematically addressed and overcome.

DOI: 10.1016/0167-7799(92)90233-L
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