Advanced search×

Bioconversion of compactin into pravastatin by Streptomyces sp.

Joo-Woong JW Park, Joo-Kyung JK Lee, Tae-Jong TJ Kwon, Dong-Hee DH Yi, Young-Jun YJ Kim, Seong-Hoon SH Moon, Hyun-Hyo HH Suh, Sang-Mo SM Kang, and Yong-Il YI Park

Biotechnol Lett 25(21):1827-31 (2003) PMID 14677706

Streptomyces sp. Y-110, isolated from soil, modified compactin to pravastatin, a therapeutic agent for hypercholesterolemia. In a batch culture, the highest production of pravastatin was 340 mg l(-1) from 750 mg compactin l(-1) in 24 h. By intermittent feeding of compactin into the culture medium, both the compactin concentration and its conversion increased to 2000 mg l(-1) and 1000 mg pravastatin l(-1), respectively, with the conversion rate of 10 mg l(-1) h(-1). Continuous feeding of compactin increased production of pravastatin to 15 mg l(-1) h(-1).

Version: za2963e q8zab q8zb2 q8zc4 q8zdc q8ze1 q8zf5 q8zgf
Buy PDF

Similar articles you may find interesting…

  1. Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system.
    Jong-Hyuk Im, Myung-Gun Kim, and Eung-Soo Kim

    J Microbiol Biotechnol 17(3):534-8 (2007) PMID 18050961

    Avermectin and its analogs are major commercial antiparasitic agents in the fields of animal health, agriculture, and human infections. To increase our understanding about the genetic mechanism underlying avermectin overproduction, comparative transcriptomes were analyzed between the low producer S....
    Buy PDF
  2. Initial development and structure of biofilms on microbial fuel cell anodes.
    Suzanne T Read, Paritam Dutta, ... Korneel Rabaey

    BMC Microbiol 10(1):98 (2010) PMID 20356407

    Biofilm viability was maintained highest nearer the anode during closed circuit operation (current flowing), in contrast to when the anode was in open circuit (soluble electron acceptor) where viability was highest on top of the biofilm, furthest from the anode. Closed circuit anode Pseudomonas aeru...
    PDF not found
  3. Detection of eubacterial 3-hydroxy-3-methylglutaryl coenzyme a reductases from natural populations of actinomycetes.
    J M JM Sigmund, D C DC Clark, ... A S AS Anderson

    Microb Ecol 46(1):106-12 (2003) PMID 12754661

    I 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA), a gene associated with isoprenoid biosynthesis. The populations were obtained from an agricultural site (69 isolates), a coastal salt marsh (220 isolates), and a desert soil (96 isolates). A set (34) of standard actinomycete reference stra...
    PDF not found