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Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial.

E J EJ Kuipers, G F GF Nelis, E C EC Klinkenberg-Knol, P P Snel, D D Goldfain, J J JJ Kolkman, H P M HP Festen, J J Dent, P P Zeitoun, N N Havu, M M Lamm, and A A Walan

Gut 53(1):12-20 (2004) PMID 14684569

Helicobacter pylori gastritis may progress to glandular atrophy and intestinal metaplasia, conditions that predispose to gastric cancer. Profound suppression of gastric acid is associated with increased severity of H pylori gastritis. This prospective randomised study aimed to investigate whether H pylori eradication can influence gastritis and its sequelae during long term omeprazole therapy for gastro-oesophageal reflux disease (GORD).

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