Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.

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Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.

Rosa F RF Hwang, Kenji K Yokoi, Corazon D CD Bucana, Rachel R Tsan, Jerald J JJ Killion, Douglas B DB Evans and Isaiah J IJ Fidler Clin Cancer Res 9(17):6534-44 (2003) PMID 14695158

We evaluated the expression of platelet-derived growth factor (PDGF) ligands and receptors in clinical specimens of human pancreatic adenocarcinomas and determined the therapeutic effect of STI571 (Gleevec), a protein tyrosine kinase inhibitor of PDGF receptor (PDGFR), on human pancreatic carcinoma cells growing in the pancreas and liver of nude mice.

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Version: za2963e q8za3 q8zb4 q8zce q8zd6 q8zef q8zf0 q8zgc

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Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.

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