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Topical 0.1% tacrolimus for the treatment of discoid lupus erythematosus and pemphigus erythematosus in dogs.

Joel D JD Griffies, Colleen L CL Mendelsohn, Wayne S WS Rosenkrantz, Rusty R Muse, Mona J MJ Boord, and Craig E CE Griffin

J Am Anim Hosp Assoc 40(1):29-41 (2004) PMID 14736903

Topical 0.1% tacrolimus was used for treatment of localized lesions associated with 10 cases of discoid lupus erythematosus (DLE) and two cases of pemphigus erythematosus (PE) either as a sole therapy (n=2) or as an adjunctive treatment (n=10). Eight of 10 dogs with DLE and both dogs with PE were improved following 8 weeks of topical application. In six of the eight dogs that improved, other medications were discontinued. No adverse effects in clinical or laboratory parameters were noted throughout the study.

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