Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infects a wide variety of insect species. A number of AcMNPV late expression factors that are involved in replication have been identified as playing a role in determining host specificity. Host cell factor-1, or HCF-1, was previously demonstrated to be essential for viral replication in Tn-368 cells. Here we demonstrate that HCF-1 is an early protein and localizes to the cell nucleus. Coprecipitation experiments revealed that HCF-1 interacts with itself but none of the other late expression factors required for replication in Tn-368 cells. HCF-1 mutants were constructed and utilized to search for the domains involved in HCF-1 biological function and oligomerization. Possible roles of HCF-1 in determining host specificity are discussed.
Studied the spectral and flux variability of IC 310 from the X-ray band to the
VHE regime. Methods. The daily light curve of IC 310 above 300 GeV has been
Measured with MAGIC from 2009 October to 2010 February. Contemporaneous
Fermi-LAT data (2008-2011) in the 10-500 GeV energy range were also an...
We systematically overexpressed 99 transcription factor genes with the nmt1 promoter and found that 64 transcription factor genes exhibited reduced fitness when ectopically expressed. Cell cycle defects were also often observed. We further investigated three uncharacterized transcription factor gene...
The emergence of heterogeneous decentralized networks without a central
controller, such as device-to-device communication systems, has created the
need for new problem frameworks to design and analyze the performance of such
networks. As a key step towards such an analysis for general networks, th...
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