Dominant genes for colorectal cancer are not rare.

doi:10.1111/j.1469-1809.1992.tb01136.x

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Dominant genes for colorectal cancer are not rare.

R S RS Houlston, A A Collins, J J Slack and N E NE Morton Ann Hum Genet 56(Pt 2):99-103 (1992) PMID 1503398

The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.

DOI: 10.1111/j.1469-1809.1992.tb01136.x
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