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On the evolution of statistical methods as applied to clinical trials.

D D Machin

J Intern Med 255(5):521-8 (2004) PMID 15078495

This paper describes how statistical methods have evolved in parallel with activities associated with randomized control trials. In particular we emphasize the pivotal role of two papers published in British Journal of Cancer, and the paper describing the Cox proportional hazards model. In addition, the importance of early papers on estimating the sample size required for trials is highlighted. Later developments including the increasing roles for competing risks, multilevel modelling and Bayesian methodologies are described. The interplay between computer software and statistical methodological developments is stressed. Finally some future directions are indicated.

DOI: 10.1111/j.1365-2796.2004.01319.x
Version: za2963e q8zaf q8zbc q8zc2 q8zdd q8ze4 q8zf7 q8zg6

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