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A novel synthesis of amino-1,2-oxazinones as a versatile synthon for beta-amino acid derivatives.

Okiko Miyata, Megumi Namba, Masafumi Ueda, and Takeaki Naito

Org Biomol Chem 2(9):1274-6 (2004) PMID 15105915

The radical addition-cyclisation of alpha, beta-unsaturated hydroxamates containing an oxime ether provides a novel method for the stereoselective synthesis of amino-1,2-oxazinones. Its synthetic utility is demonstrated by a stereoselective synthesis of beta-amino acid derivatives, such as alpha-alkyl-beta-amino-gamma-lactone and alpha,beta-disubstituted beta-lactam.

DOI: 10.1039/b403694h
Version: za2963e q8za8 q8zbb q8zc7 q8zd8 q8ze5 q8zf6 q8zg4
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