The chicken major histocompatibility (B) complex (MHC) affects disease outcome significantly. One of the best characterized systems of MHC control is the response to the oncogenic retrovirus, Rous sarcoma virus (RSV). Genetic selection altered the tumor growth pattern, either regressively or progressively, with the data suggesting control by one or a few loci. Particular MHC genotypes determine RSV tumor regression or progression indicating the crucial B complex role in Rous sarcoma outcome. Analysis of inbred lines, their crosses, congenic lines, and noninbred populations has revealed the anti-RSV response of many B complex haplotypes. Tumor growth disparity among lines identical at the MHC but differing in their background genes suggested a non-MHC gene contribution to tumor fate. Genetic complementation in tumor growth has also been demonstrated for MHC and non-MHC genes. RSV tumor expansion reflects both tumor cell proliferation and viral replication generating new tumor cells. In addition, the B complex controls tumor growth induced by a subviral DNA construct encoding only the RSV v-src oncogene. Immunity to subsequent tumors and metastasis also exhibit MHC control. Genotypes that regressed either RSV or v-src DNA primary tumors had enhanced protection against subsequent homologous challenge. Regressor B genotypes had lower tumor metastasis compared with progressor types. Together, the data indicate that B complex control of RSV tumor fate is strongly defined by the response to a v-src-determined function. Differential RSV tumor outcomes among various B genotypes may include immune recognition of a tumor-specific antigen or immune system influences on viral replication.
We investigate the effects of local population structure in
Reaction-diffusion processes on metapopulations represented as complex
Networks. Considering a model in which the nodes of a large scale network
Represent local populations defined in terms of a homogeneous graph, we show by
Means of extens...
Multi-wavelength high-resolution observations of a rare merger of two massive
SMGs at z = 2.3. The system is currently forming stars at a tremendous rate of
2,000 M_sun/yr. With a star formation efficiency an order-of-magnitude greater
Than that of normal galaxies, it will quench the star...
The magnetization switching of a thin ferromagnetic layer placed on top of a
heavy metal (such as Pt, Ta or W) driven by an in-plane current has been
observed in recent experiments. The magnetization dynamics of these processes
is studied in a full micromagnetic framework which takes into account t...
Pubget Updates sends you emails when Pubget finds new papers that match your search. Use Pubget Updates to get the latest articles for your specialty, written by a colleague, or published by your favorite journals.