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CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency.

Kathy A KA Green, Cory L CL Ahonen, W James WJ Cook, and William R WR Green

J Virol 78(11):6055-60 (2004) PMID 15141004 PMCID 415804

LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.

DOI: 10.1128/JVI.78.11.6055-6060.2004
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