Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.
S K SK Hansen,
A P AP Gjesing,
S K SK Rasmussen,
C C Glümer,
S A SA Urhammer,
G G Andersen,
C S CS Rose,
T T Drivsholm,
S K SK Torekov,
D P DP Jensen,
C T CT Ekstrøm,
K K Borch-Johnsen,
T T Jørgensen,
M I MI McCarthy,
T T Hansen and
O O Pedersen
Diabetologia 47(6):1079-87 (2004)
PMID 15170498
The class III allele of the variable-number-of-tandem-repeats polymorphism located 5' of the insulin gene (INS-VNTR) has been associated with Type 2 diabetes and altered birthweight. It has also been suggested, although inconsistently, that the class III allele plays a role in glucose-induced insulin response among NGT individuals.
DOI: 10.1007/s00125-004-1418-3
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