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Characterization of mild coagulation factor VII deficiency: activity and clearance of the Arg315Trp and Arg315Lys variants in the Cys310-Cys329 loop (c170s).

Christian Furlan Freguia, Raffaella Toso, Eleanor S Pollak, Valder R Arruda, Mirko Pinotti, and Francesco Bernardi

Haematologica 89(12):1504-9 (2004) PMID 15590402

Arginine 315 in factor VII (FVII) belongs to a solvent-exposed loop involved in direct interaction with the co-factor (tissue factor, TF), in transmission of TF-induced effects and potentially in FVIIa inactivation. Natural FVII variants at position 315 provide peculiar models for structure-function studies.

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