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Physiological (osmotic fragility) and morphological effects on red blood cells: action of phytic acid and stannous fluoride.

Guilherme L Lima-Filho, Glaydes M T Lima, Silvana R F Moreno, Luiz C M Aleixo, Sebastião D Santos-Filho, Rosimeire S Freitas, Vilma G B Melo, and Mario Bernardo-Filho

Can J Physiol Pharmacol 82(12):1091-5 (2004) PMID 15644951

Phytic acid occurs in foods derived from plants. We have investigated the possibility that phytic acid and stannous fluoride are capable of altering the physiological properties (osmotic fragility) and morphological properties of red blood cells (RBC). Osmotic fragility was unchanged by the presence of phytic acid and stannous fluoride in the studied concentrations, but RBC morphology was modified in the presence of the studied substances. In conclusion, the alterations to RBC morphology were not sufficient to promote modifications in osmotic fragility. Our results suggest that the chelating properties of phytic acid could be responsible for the observed effects.

DOI: 10.1139/y04-110
Version: za2963e q8za7 q8zb6 q8zcc q8zdd q8ze1 q8zf4 q8zg7

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