Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a crucial role in adipocyte differentiation, glucose metabolism, and other physiological processes. To further explore the role of PPARgamma in adipose tissues, we used a Cre/loxP strategy to generate adipose-specific PPARgamma knockout mice. These animals exhibited marked abnormalities in the formation and function of both brown and white adipose tissues. When fed a high-fat diet, adipose-specific PPARgamma knockout mice displayed diminished weight gain despite hyperphagia, had diminished serum concentrations of both leptin and adiponectin, and did not develop glucose intolerance or insulin resistance. Characterization of in vivo glucose dynamics pointed to improved hepatic glucose metabolism as the basis for preventing high-fat diet-induced insulin resistance. Our findings further illustrate the essential role for PPARgamma in the development of adipose tissues and suggest that a compensatory induction of hepatic PPARgamma may stimulate an increase in glucose disposal by the liver.
Two questions related to elastic motions are raised and addressed. First: in
which theoretical framework can the equations of motion be written for an
elastic half-space put into uniform rotation? It is seen that nonlinear finite
elasticity provides such a framework for incompressible solids. Secon...
We introduce a novel approach to non-invasively
Measure the optical transmission-matrix inside a scattering medium, exploiting
The photo-acoustic effect. Our approach allows for the first time to
Simultaneously discriminate, localize, and selectively focus light on multiple
Targets inside a scatteri...
We present dynamical models of four interacting systems: NGC 5257/8, The
Mice, the Antennae, and NGC 2623. The parameter space of the encounters are
Constrained using the Identikit model-matching and visualization tool.
Identikit utilizes hybrid N-body and test particle simulations to enable rapid
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