- Results
- This Paper
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.
Shiro S Maeda, Shuichi S Tsukada, Akio A Kanazawa, Akihiro A Sekine, Tatsuhiko T Tsunoda, Daisuke D Koya, Hiroshi H Maegawa, Atsunori A Kashiwagi, Tetsuya T Babazono, Masafumi M Matsuda, Yasushi Y Tanaka, Tomoaki T Fujioka, Hiroshi H Hirose, Takashi T Eguchi, Yoichi Y Ohno, Christopher J CJ Groves, Andrew T AT Hattersley, Graham A GA Hitman, Mark M Walker, Kohei K Kaku, Yasuhiko Y Iwamoto, Ryuzo R Kawamori, Ryuichi R Kikkawa, Naoyuki N Kamatani, Mark I MI McCarthy and Yusuke Y Nakamura
J Hum Genet 50(6):283-92 (2005)
PMID 15940393
To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor-activating protein 2beta (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: chi(2)=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); chi(2)=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); chi(2)=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.
DOI:
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DOI:
Version: za2963e q8zad q8zb8 q8zc8 q8zd3 q8zec q8zfe q8zg5