The pancreatic ATP-sensitive potassium channels comprise two subunits: SUR1 and Kir6.2. Two SUR1 mutations, A116P and V187D, reduce channel activity causing persistent hyperinsulinemic hypoglycemia of infancy. We investigated whether these mutations cause temperature sensitive misfolding. We show that the processing defect of these mutants is temperature sensitive and these two mutations disrupt the association between SUR1 and Kir6.2 by causing misfolding in SUR1 at 37^oC but can be rescued at 18^oC. Extensive electrophysiological characterization of these mutants indicated that low temperature largely, if not completely, corrects the folding defect of these two SUR1 mutants observed at 37^oC.
We have measured the zero bias peak in differential conductance in a hole
Quantum dot. We have scaled the experimental data with applied bias and
Compared to real time renormalization group calculations of the differential
Conductance as a function of source-drain bias in the limit of zero temperatu...
NADP-malic enzyme (NADP-ME) is involved in different metabolic pathways in several organisms due to the relevant physiological functions of the substrates and products of its reaction. In plants, it is one of the most important proteins that were recruited to fulfil key roles in C4 p...
We present a first observational investigation
Of these anomalies across a range of conditions and transitions by carrying out
A survey of low-mass starless cores (in Taurus & Ophiuchus) and high-mass
Protostellar objects (in the G333 giant molecular cloud) using hydrogen cyanide
(HCN) J=1-0 and J=3...
Pubget Updates sends you emails when Pubget finds new papers that match your search. Use Pubget Updates to get the latest articles for your specialty, written by a colleague, or published by your favorite journals.