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Histologic evaluation of periradicular tissues in dogs treated with calcium hydroxide in combination with HCT20 and camphorated P-chlorophenol

Roberto Machado RM Cruz and Sergio Valmor SV Barbosa

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100(4):5 (2005) PMID 16182173

Objective: The aim of this study was to evaluate the biocompatibility of calcium hydroxide suspended in HTC20 or calcium hydroxide plus CMCP and their effects on the healing of periapical lesions in dogs. Study design: Experimental apical periodontitis was induced by opening the pulp chamber of 36 mandibular premolars in 6 3-year old dogs. The teeth were left opened for 1 week and then closed with IRM for 60 days in order to induce periapical lesions. The teeth were divided into 1 control and 2 experimental groups. Both experimental groups received intracanal dressings with a calcium hydroxide slurry. In the first experimental group calcium hydroxide was mixed with a detergent vehicle and in the second group with camphorated parachlorophenol. The medications were kept in the root canal for 2 periods of 30 days each. Afterwards, the dogs were killed and the periapical areas were studied histologically. Results: Based on biocompatibility and tissue remodeling in the periapical area, the best results were observed when calcium hydroxide was mixed with the detergent. The difference was statistically significant (P <.05). Conclusion: Calcium hydroxide plus CMCP intracanal dressing was the most irritating to the periapical region, and the group of calcium hydroxide plus HCT 20 showed the best results whenever biocompatibility and the capacity of new bone formation was considered.

Copyright © 2005 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.tripleo.2004.05.019
Version: za2963e q8za7 q8zb6 q8zc6 q8zd8 q8zed q8zfd q8zg6

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