Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat.
The adipokine adiponectin has insulin-sensitising, anti-atherogenic and anti-inflammatory properties. Recently, the genes for mouse and human adiponectin receptor-1 (ADIPOR1) and -2 (ADIPOR2) have been cloned. The aim of this study was to investigate whether genetic variants of the genes encoding ADIPOR1 and ADIPOR2 play a role in human metabolism.
DOI: 10.1007/s00125-005-1948-3
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