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Spinal muscarinic and nicotinic subtypes activated by clonidine in postincisional pain.

Frédéric F Duflo, Emmanuel E Boselli, Philippe P Ryvlin, and Dominique D Chassard

Anesthesiology 103(6):1253-8 (2005) PMID 16306740

A recent model of acute incisional pain has been characterized that strongly parallels the postoperative period in patients experiencing evoked pain. In that setting, abundant literature has revealed antihypersensitive effects produced by intrathecally administered alpha2-adrenergic receptor agonists, such as clonidine, in both animals and humans. Recent reports have suggested an obligatory role of spinal acetylcholine receptors in the analgesic action of intrathecal clonidine. The authors sought to determine the involvement of spinal muscarinic and nicotinic receptor subpopulations in the antihypersensitivity effect of intrathecal clonidine in a rodent model for human postoperative pain.

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