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CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia.

Shinichi S Inomata, Atsushi A Nagashima, Fumio F Itagaki, Masato M Homma, Masuhiro M Nishimura, Yoshiko Y Osaka, Kazuhiko K Okuyama, Einosuke E Tanaka, Takako T Nakamura, Yukinao Y Kohda, Shinsaku S Naito, Masayuki M Miyabe, and Hidenori H Toyooka

Clin Pharmacol Ther 78(6):647-55 (2005) PMID 16338280

Diazepam is widely used to relieve preoperative anxiety in patients. The objective of this study was to investigate the effects of polymorphism in CYP2C19 and the effects of CYP3A4 messenger ribonucleic acid (mRNA) content in blood on recovery from general anesthesia and on diazepam pharmacokinetics.

Copyright © 2005 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.clpt.2005.08.020
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