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Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin.

E E Campalani, M H MH Allen, D D Fairhurst, H S HS Young, C O CO Mendonca, A D AD Burden, C E M CE Griffiths, M A MA Crook, J N W N JN Barker, and C H CH Smith

Br J Dermatol 154(2):345-52 (2006) PMID 16433808

Psoriasis is associated with abnormal plasma lipid metabolism and a high frequency of cardiovascular events. Increased lipid levels are also seen in patients with psoriasis treated with acitretin. Apolipoprotein E (ApoE) variants have been linked to hypertriglyceridaemia and hypercholesterolaemia in normal individuals. Two coding single nucleotide polymorphisms at +3937 and +4075 define the three common ApoE alleles e2, e3 and e4.

DOI: 10.1111/j.1365-2133.2005.06950.x
Version: za2963e q8zaa q8zbe q8zc5 q8zd2 q8zeb q8zf0 q8zga

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