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Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation.

Verawan Uchaipichat, Leanne K Winner, Peter I Mackenzie, David J Elliot, J Andrew Williams, and John O Miners

Br J Clin Pharmacol 61(4):427-39 (2006) PMID 16542204 PMCID 1885031

Using the fluconazole-zidovudine (AZT) interaction as a model, to determine whether inhibition of UDP-glucuronosyltransferase (UGT) catalysed drug metabolism in vivo could be predicted quantitatively from in vitro kinetic data generated in the presence and absence bovine serum albumin (BSA).

DOI: 10.1111/j.1365-2125.2006.02588.x
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