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In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis.

Barbara J BJ Hoeben, David S DS Burgess, Jason T JT McConville, Laura K LK Najvar, Robert L RL Talbert, Jay I JI Peters, Nathan P NP Wiederhold, Bradi L BL Frei, John R JR Graybill, Rosie R Bocanegra, Kirk A KA Overhoff, Prapasri P Sinswat, Keith P KP Johnston, and Robert O RO Williams

Antimicrob Agents Chemother 50(4):1552-4 (2006) PMID 16569882 PMCID 1426984

Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

DOI: 10.1128/AAC.50.4.1552-1554.2006
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