To investigate the potential utility of a new combined immunostaining technique for diagnosing prostate cancer from histological analysis of needle biopsy specimens.
Tissue was immunostained with a combination of antibodies against a basal cell marker (p63), and an enzyme commonly overexpressed in prostate cancer (p504s), on 63 small prostate cancer foci (<1 mm) and 109 cases of ambiguous lesions observed in needle biopsies.
After p63/p504s immunostaining, 93% of the ambiguous lesions (102/109) were classified. The final diagnoses retained were: 92 prostate cancers, seven atypical small acinar proliferations suspected of being malignant but undiagnosed, 21 prostatic intraepithelial neoplasia, five atypical adenomatous hyperplasia, and 36 atrophic benign mimickers of cancer.
Combining p504s as a positive marker for prostate cancer and p63 as a negative marker might improve diagnostic performance, sensitivity and specificity, and lead to fewer false-negative results. This simple immunostaining procedure should reduce the percentage of residual ambiguous lesions and the need for additional biopsies.
We demonstrate embedded growth of cortical mouse neurons in dense arrays of
Semiconductor microtubes. The microtubes, fabricated from a strained
GaAs/InGaAs heterostructure, guide axon growth through them and enable
Electrical and optical probing of propagating action potentials. The coaxial
This paper evaluated the spatiotemporal non-stationarity in the vegetation dynamic based on 1-km resolution 16-day composite Moderate Resolution Imaging Spectroradiometer (MODIS) Enhanced Vegetation Index (EVI) datasets in China during 2001-2011 through a wavelet transform method. Fi...
We study Bessel beams of two-level atoms that are driven by a linearly
Polarized laser field. Starting from the Schroedinger equation, we determine
The states of two-level atoms in a plane-wave field respecting propagation
Directions both of the atom and the field. For such laser-driven two-level
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