Understanding the fundamental steps of virus life cycles including virus-host interactions is essential for the design of effective antiviral strategies. Such understanding has been deferred by the complexity of higher eukaryotic host organisms. To circumvent experimental difficulties associated with this, systems were developed to replicate viruses in the yeast Saccharomyces cerevisiae. The systems include viruses with RNA and DNA genomes that infect plants, animals and humans. By using the powerful methodologies available for yeast genetic analysis, fundamental processes occurring during virus replication have been brought to light. Here, we review the different viruses able to direct replication and gene expression in yeast and discuss their main contributions in the understanding of virus biology.
We demonstrate how
To hybridize Bloch bands in optical lattices to introduce long-range
Ferromagnetic order in an itinerant atomic system. We find spontaneously broken
Symmetry for bosons with a double-well dispersion condensing into one of two
Distinct minima, which we identify with spin-up and spi...
We propose a formal definition of an ABox module, such
That it guarantees complete preservation of facts of a given set of
Individuals, and thus can be reasoned independently w.r.t. the ontology TBox.
With ABox modules of this type, isolated or distributed (parallel) ABox
Reasoning becomes feasible,...
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