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Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication

Isabel Alves-Rodrigues, Rui Pedro Galão, Andreas Meyerhans, and Juana Díez

Virus Res 120(1-2):8 (2006) PMID 16698107

Understanding the fundamental steps of virus life cycles including virus-host interactions is essential for the design of effective antiviral strategies. Such understanding has been deferred by the complexity of higher eukaryotic host organisms. To circumvent experimental difficulties associated with this, systems were developed to replicate viruses in the yeast Saccharomyces cerevisiae. The systems include viruses with RNA and DNA genomes that infect plants, animals and humans. By using the powerful methodologies available for yeast genetic analysis, fundamental processes occurring during virus replication have been brought to light. Here, we review the different viruses able to direct replication and gene expression in yeast and discuss their main contributions in the understanding of virus biology.

Copyright © 2006 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.virusres.2005.11.018
Version: za2963e q8za2 q8zb0 q8zc3 q8zd1 q8zec q8zf4 q8zgb

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