Comment on Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens and Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.

doi:10.1126/science.1122712

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Comment on Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens and Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.

Mathias M Currat, Laurent L Excoffier, Wayne W Maddison, Sarah P SP Otto, Nicolas N Ray, Michael C MC Whitlock and Sam S Yeaman crossref 313(5784):172; author reply 172 14 Jul 2006 PMID 16840683

Mekel-Bobrov et al. and Evans et al. (Reports, 9 Sept. 2005, p. 1720 and p. 1717, respectively) examined sequence data from modern humans within two gene regions associated with brain development, ASPM and microcephalin, and concluded that selection of these genes must be ongoing. We show that models of human history that include both population growth and spatial structure can generate the observed patterns without selection.

DOI: 10.1126/science.1122712
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