Advanced search×

Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms.

Clifford B Saper

Prog Brain Res (2006) PMID 16876579

Daily patterns of sleep and wakefulness are inextricably linked to the regulation of feeding and energy metabolism. Both are affected by homeostatic as well as circadian drives, and both are tightly linked to thermoregulation. In this chapter, we review the basic drain circuitry that regulates sleep and wakefulness, including the flip-flop switch relationship of the arousal system and the ventrolateral preoptic sleep-promoting neurons. We then examine the role of the orexin/hypocretin neurons, which stabilize the switch while driving both wakefulness and foraging for food. We also review the role of the subparaventricular nucleus and the dorsomedial nucleus of the hypothalamus in circadian integration and modulation of both feeding and wake-sleep patterns.

DOI: 10.1016/S0079-6123(06)53014-6
Version: za2963e q8za5 q8zb8 q8zc4 q8zd2 q8ze2 q8zf0 q8zg4

Similar articles you may find interesting…

  1. Central control of thermogenesis in mammals.
    Shaun F Morrison, Kazuhiro Nakamura, and Christopher J Madden

    Exp Physiol 93(7):773-97 (2008) PMID 18469069

    Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature in mammals and birds during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile response to infection. T...
  2. N-butyl Cyanoacrylate Embolization for Pseudoaneurysms Complicating Pancreatitis or Pancreatectomy
    Kenta Izaki, Masato Yamaguchi, ... Koji Sugimoto

    J Vasc Interv Radiol 22(3):7 (2011) PMID 21353983

    We encountered additional bleeding vessels at 11, 33, and 49 days after the procedures, which were successfully managed by a second embolization in each case. There were no major complications related to the procedures. As minor complications, in two procedures, the embolized material overflowed bey...