Advanced search×

The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice.

R L RL Rabenstein, B J BJ Caldarone, and M R MR Picciotto

Psychopharmacology (Berl) 189(3):395-401 (2006) PMID 17016705

Increases in cholinergic transmission are linked to depression in human subjects and animal models. We therefore examined the effect of decreasing nicotinic acetylcholine receptor (nAChR) activity in tests of antidepressant efficacy using C57BL/6J mice.

DOI: 10.1007/s00213-006-0568-z
Version: za2963e q8za9 q8zbe q8zc1 q8zd0 q8zed q8zfc q8zg2

Similar articles you may find interesting…

  1. Association of the NRG1 gene and schizophrenia: a meta-analysis.
    M R MR Munafò, D L DL Thiselton, ... J J Flint

    Mol Psychiatry 11(6):539-46 (2006) PMID 16520822

    We investigated the association of the NRG1 gene and schizophrenia using meta-analytic techniques, combining all published data while restricting our analysis to studies investigating the most commonly reported single marker (SNP8NRG221533). We also investigated whether ancestry (European vs East As...
  2. Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
    M Shaikh, M-H Hall, ... E Bramon

    Psychol Med 41(2):263-76 (2011) PMID 20102668

    Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and...
  3. Molecular and cellular characterization of Neuregulin-1 type IV isoforms.
    Alon A Shamir and Andres A Buonanno

    J Neurochem 113(5):1163-76 (2010) PMID 20218976

    We determined that the initiation site is 23 bp upstream of the previously reported type IV exon, and that no other transcripts map to the SNP8NRG243177 region. Because NRG1 type IV transcripts are specific to human, we isolated full-length NRG1 type IV cDNAs from human hippocampi and expressed them...
    View PDF