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Crystal Structure of a Multi-domain Immunophilin from Arabidopsis thaliana: A Paradigm for Regulation of Plant ABC Transporters

Joachim Granzin, Andreas Eckhoff, and Oliver H Weiergräber

J Mol Biol 364(4):11 (2006) PMID 17045295

FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants. We present the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 A resolution. The data shed light on the probable binding modes of key interaction partners, including HSP90 and two classes of ABC transporters. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.

Copyright © 2006 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.jmb.2006.09.052
Version: za2963e q8zac q8zb1 q8zcc q8zd5 q8zee q8zfa q8zg4

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