Dietary fibre consumption is known to be beneficial to increase stool bulk and frequency. In contrast, it is unclear whether chronic dietary fibre deficiency affects colonic motor functions, especially neuronally mediated muscle contractions. In this study, rats were fed a fibre-free diet or diet containing dietary fibre (cellulose or guar gum) for 27 days. Furthermore, neurogenic and myogenic contractions were evaluated in circular and longitudinal muscle strips of the distal colon. Additionally, the number of enterochromaffin (EC) cells, which play important roles in the initiation of the peristaltic reflex, was also examined by immunohistochemistry for serotonin. Myogenic contractions induced by carbachol or substance P were examined in the presence of tetrodotoxin. Circular muscle was hyposensitive to carbachol, but longitudinal muscle was hypersensitive to substance P in the fibre-free group. Nerve-mediated circular (5-20 Hz) and longitudinal (1-2 Hz) muscle contractions evoked by electrical field stimulation were attenuated in the fibre-free group and the latter response was almost abolished by atropine, suggesting functional changes of cholinergic neurons. EC cell number was decreased in the fibre-free group. In conclusion, changes in neurogenic and myogenic contractions and a decrease in EC cell number observed may affect colonic motility of the fibre-free group.
We establish the regularity theory for certain critical elliptic systems with
An anti-symmetric structure under inhomogeneous Neumann and Dirichlet boundary
Constraints. As applications, we prove full regularity and smooth estimates at
The free boundary for weakly Dirac-harmonic maps from spin Riema...
We present the first full characterisation of such a device to
Test its functional limits and potential for DI-QKD. This device is tested at
Telecom wavelengths and is shown to be capable of overcoming losses
Corresponding to a transmission through $20\, \rm km$ of single mode telecom
Fibre. We demo...
• The mean blood loss, mean length of hospital stay and mean operating time, stone-free rates and postoperative complications in the two groups were compared using the t-test or chi-squared test (Fisher's exact test). • The plasma vaporization group had a significantly lower mean (sd) decr...
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