LP-BM5, a retroviral isolate, induces a disease featuring an acquired immunodeficiency syndrome termed murine AIDS (MAIDS). Many of the features of the LP-BM5-initiated disease are shared with HIV/AIDS. Our lab has shown that the interaction of B and CD4 T cells that is central to MAIDS pathogenesis requires ligation of CD40 on B cells by CD154 on CD4 T cells. Despite this strict requirement for CD154 expression, whether CD4 T cell receptor (TCR) occupancy is essential for the induction of MAIDS is unknown. To block TCR engagement, Tg mouse strains with monoclonal TCR of irrelevant peptide/MHC specificities, all on MAIDS-susceptible genetic backgrounds, were tested: the study of a panel of TCR Tg CD4 T cells controlled for the possibility of serendipitous crossreactive recognition of virus-associated or induced-self peptide, or superantigen, MHC complexes by a given TCR. The results argue that TCR engagement is not necessary for the induction of MAIDS.
We present an analytical theory of the growth of a large-scale mean magnetic
Field in a linear shear flow with fluctuations in time of the alpha parameter
(equivalently, kinetic helicity). Using shearing coordinates and Fourier
Variables we derive a set of coupled integro-differential equations, gov...
Our algorithm iterates
over tuples in the given user-permission relation, uses selected tuples as
seeds for constructing candidate rules, and attempts to generalize each
candidate rule to cover additional tuples in the user-permission relation by
replacing conjuncts in attribute expressions with con...
We have previously
Shown that a Schnakenberg-type Turing mechanism can recapitulate the branching
And protein expression patterns in wildtype and mutant lungs, but it is unclear
Whether this mechanism would extend to other branched organs that are regulated
By other proteins. Here we show that the G...
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