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Effect of exogenous glucocorticoid on osmotically stimulated antidiuretic hormone secretion and on water reabsorption in man.

Volker V Bähr, Norma N Franzen, Wolfgang W Oelkers, Andreas F H AF Pfeiffer, and Sven S Diederich

Eur J Endocrinol 155(6):845-8 (2006) PMID 17132754

Glucocorticoids exert tonic suppression of antidiuretic hormone (ADH) secretion. Hypocortisolism in secondary adrenocortical insufficiency can result in a clinical picture similar to the syndrome of inappropriate ADH secretion. On the other hand, in vitro and in vivo results provide evidence for ADH suppression in states of hypercortisolism. To test the hypothesis that ADH suppression is of relevance during glucocorticoid therapy, we investigated the influence of prednisolone on the osmotic stimulation of ADH.

DOI: 10.1530/eje.1.02299
Version: za2963e q8zaa q8zb7 q8zc4 q8zdb q8zea q8zf8 q8zge

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