Advanced search×

White blood cell sister chromatid exchange among a sample of Thai subjects exposed to toluene, an observation.

Viroj V Wiwanitkit, Jamsai J Suwansaksri, and Suphan S Soogarun

Int J Exp Pathol 87(6):501-3 (2006) PMID 17222218

There is a particular concern with toluene because some research has indicated that toluene exposure could result in chronic toxicity including mutagenesis and carcinogenesis. This study aimed to determine the rate of sister chromatid exchanges (SCE), a marker for genotoxicity, and its correlation to the classical urine biomarker for toluene exposure, urine hippuric acid, among a sample of Thai exposed subjects. A total of 26 police (all males) were included in this study. The average (mean +/- SD) urine hippuric acid level in these police was 0.8 +/- 0.4 mg/g creatinine. The average (mean +/- SD) SCE level in these police was 4.5 +/- 1.0/cell. The average SCE among the police with high urine hippuric acid levels was non-significantly higher than the average SCE level of those without (P = 0.41). This implies that the cytogenetic response to toluene was not different between the subjects with and without high toluene exposure. High exposure to toluene seems not to be related to high SCE.

DOI: 10.1111/j.1365-2613.2006.00496.x
Version: za2963e q8zaa q8zb7 q8zc0 q8zda q8ze4 q8zf6 q8zge
View PDF

Similar articles you may find interesting…

  1. Association of microparticles and preeclampsia.
    Fabiana K Marques, Fernanda M F Campos, and Karina B Gomes

    Mol Biol Rep (2013) PMID 23645085

    Preeclampsia (PE) is a syndrome characterized by poor placentation and endothelial dysfunction. The diagnosis for this syndrome is based in hypertension and proteinuria presented after the 20th week of pregnancy. Despite intensive research, PE is still one of the leading causes of ma...
  2. Endothelial Shc Regulates Arteriogenesis Through Dual Control of Arterial Specification and Inflammation via the Notch and NF-κB Pathways.
    Daniel T Sweet, Zhongming Chen, and Ellie Tzima

    Circ Res (2013) PMID 23661718

    Shc mediates activation of two key signaling pathways that are critical for inflammation and arterial specification; collectively, these pathways contribute to arteriogenesis and recovery of blood perfusion....
  3. Importance of Donor Ethnicity/Race Matching in Unrelated Adult and Cord Blood Allogeneic Hematopoietic Cell Transplantation.
    Celalettin Ustun, Veronika Bachanova, and Daniel J Weisdorf

    Leuk Lymphoma (2013) PMID 23647059

    Donor race matching (both recipients and donors belonging to the same race) might be a factor in outcomes of donor allogeneic hematopoietic cell transplantation (alloHCT). A total of 858 patients who underwent umbilical cord blood (UCB) (475 patients: 202 double UCB and 273 single UC...