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Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness.

Michael G Martin, Nicole L Whitlatch, Bijal Shah, and Gowthami M Arepally

Am J Hematol 82(7):679-81 (2007) PMID 17266059

We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient. The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole. Other symptoms of drug hypersensitivity included nausea, vomiting, urticarial rash, and leukopenia. Because of her religious faith, the patient was supported without plasma therapy with use of intravenous immunoglobulin, steroids, rituximab, and erythropoietin.

DOI: 10.1002/ajh.20887
Version: za2963e q8za2 q8zbd q8zc3 q8zdb q8ze9 q8zf3 q8zg0

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