Advanced search×

The application of the combined corticotropin-releasing hormone plus desmopressin stimulation during petrosal sinus sampling is both sensitive and specific in differentiating patients with Cushing's disease from patients with the occult ectopic adrenocorticotropin syndrome.

S S Tsagarakis, D D Vassiliadi, I S IS Kaskarelis, J J Komninos, E E Souvatzoglou, and N N Thalassinos

J Clin Endocrinol Metab 92(6):2080-6 (2007) PMID 17356045

Although bilateral inferior petrosal sinus sampling (BIPSS) with CRH stimulation is the most accurate procedure for the differential diagnosis of ACTH-dependent Cushing's syndrome (CS), 4-15% of patients with Cushing's disease (CD) fail to demonstrate diagnostic gradients. Preliminary data suggest that a more potent stimulation by the combined administration of CRH plus desmopressin during BIPSS may provide some diagnostic advantage. A crucial issue, however, is whether such an amplified stimulation may affect the specificity of the procedure, and this was the main aim of the present study.

DOI: 10.1210/jc.2006-2691
Version: za2963e q8za2 q8zb6 q8zcc q8zd0 q8zec q8zf9 q8zg9

Similar articles you may find interesting…

  1. Reproducibility of the corticotropin stimulation test in septic shock.
    Ioanna I Dimopoulou, Maria M Zervou, ... Stylianos S Tsagarakis

    Anesth Analg 103(4):1056-7; author reply 1057 (2006) PMID 17000852

  2. Role of [(18)F]FDG-PET/CT in the detection of occult recurrent medullary thyroid cancer.
    Evangelia E Skoura, Phivi P Rondogianni, ... Ioannis E IE Datseris

    Audio, Transactions of the IRE Profession... 31(6):567-75 (2010) PMID 20335822

    Among the 38 [(18)F]FDG-PET/CT scans there were 18 positive and 20 negative scans. Out of the 18 positive scans, 17 were true positive and one false positive. These findings suggest that [(18)F]FDG-PET/CT provides additional information in almost half of all cases (overall per patient sensitivity of...