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Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis-A flow cytometric study

Nighat N Nazir, Surrinder S Koul, Mushtaq A MA Qurishi, Sachin C SC Taneja, Sheikh F SF Ahmad, Sarang S Bani, and Ghulam N GN Qazi

J Ethnopharmacol 112(2):5 (2007) PMID 17408893

Bergenin (1), a C-glycoside of 4-O-methyl gallic acid, isolated from rhizomes of Bergenia stracheyi (Saxifragaceae) and its O-demethylated derivative norbergenin (2), prepared from 1, are reported to show anti-arthritic activity through possible modulation of Th1/Th2 cytokine balance. Flow cytometric study showed that the oral administration of 1 and 2 at doses of 5, 10, 20, 40 and 80mg/kg per oral dose inhibit the production of proinflammatory Th1 cytokines (IL-2, IFN-@c and TNF-@a) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice. This shows the potential Th1/Th2 cytokine balancing activity of 1 and 2 which is strongly correlated with their anti-arthritic activity. At similar dose levels, the effect of 2 was found to be more than that of 1. The oral LD"0 for 1 and 2 was more than 2000mg/kg body weight of the mice.

Copyright © 2007 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.jep.2007.02.023
Version: za2963e q8za6 q8zb5 q8zca q8zdb q8zec q8zfb q8zg4

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