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Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate.

Zia R ZR Tayab, Tom C TC Fardon, Daniel K C DK Lee, Kay K Haggart, Lesley C LC McFarlane, Brian J BJ Lipworth, and Günther G Hochhaus

Br J Clin Pharmacol 64(5):698-705 (2007) PMID 17509041 PMCID 2203259

Fluticasone propionate (FP) and mometasone furoate (MF) are inhaled corticosteroids that possess a high ratio of topical to systemic activity. The systemic bioavailability of MF has been claimed to be minimal (1%). FP has been shown to exhibit the same degree of systemic effects, but its systemic availability is between 13 and 17%. We hypothesize that FP and MF have comparable systemic availabilities that can explain their potential to cause systemic effects.

DOI: 10.1111/j.1365-2125.2007.02919.x
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