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Agonist lead identification for the high affinity niacin receptor GPR109a

Bioorganic & Medicinal Chemistry Letters 17(17):4914 (2007) PMID 17588745

A strategy for lead identification of new agonists of GPR109a is described. Early compound triage led us to focus on a series of pyrazole acid derivatives. Further elaboration of these compounds provided a series of 5,5-fused pyrazoles to be used as lead compounds for further optimization.

DOI: 10.1016/j.bmcl.2007.06.028