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The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras.

Shengxiu S Li, Dan D Goldowitz, and Douglas J DJ Swanson

Invest Ophthalmol Vis Sci 48(7):3292-300 (2007) PMID 17591901

The small eye mouse mutant (Sey) is caused by a mutation of the Pax6 gene. Previous studies, in which aggregation chimeras were used, have demonstrated that Sey/Sey cells contribute poorly to the neural retina forming small clumps of cells restricted to the inner retina at embryonic day 16.5. In addition, Sey/+ cells are absent from the lens epithelium during this embryonic period and postnatally. This study was conducted to determine the fates of these Sey/Sey and Sey/+ cells with continued development in chimeric mouse eyes.

References 42 articles

DOI: 10.1167/iovs.06-1482
Version: za2963e q8zad q8zbf q8zc3 q8zdc q8ze5 q8zfd q8zg0

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