Leucine-rich repeat containing protein 10 (LRRC10) is a heart-specific factor whose function remains unknown. Examination of the intracellular location of the gene products is a critical step in determining the biological functions of the protein. Our expression analyses in mice indicate that LRRC10 is exclusively expressed from the precardiac region in early embryos to the adult heart. LRRC10 expression is markedly elevated upon birth, suggesting its role in the embryonic as well as adult hearts. Of interest, LRRC10 exhibits dynamic intracellular expression patterns in cardiomyocytes. Cardiomyocytes from embryos and newborns show diffuse cytoplasmic and nuclear staining of LRRC10. In contrast, striking striations are observed in adult cardiomyocytes, which are colocalized with the markers for the Z-line, sarcoplasmic reticulum (SR), and transverse (T)-tubule by double immunostaining. Further investigation by electron micrographs places LRRC10 in a diad region where the SR interacts with the T-tubule that locates along the Z-line.
We present here compelling empirical evidence of a high level of
Regularity regarding time and spatial correlations in urban sprawl, unraveling
Patterns about the inertia in the growth of cities and their interaction with
Each other. By using one of the world's most exhaustive extant demographic dat...
We introduce an epidemiological model where infectives leave the
Epidemic, either by recovery or sampling, after some random time which may
Follow an arbitrary distribution.
We derive an expression for the likelihood of the phylogenetic tree of
Sampled infectives under our general epidemiological...
We analytically solve the equations of motion in a
Collective-coordinate framework for this type of anisotropic exchange system,
To investigate the domain wall dynamics in detail. In particular, we obtain
Analytical expressions for the maximum attainable domain wall velocity of such
A setup and also...
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