Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells.

doi:10.1359/jbmr.070721

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Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells.

Weimin W Qiu, Tom E TE Andersen, Jens J Bollerslev, Susanne S Mandrup, Basem M BM Abdallah and Moustapha M Kassem J Bone Miner Res 22(11):1720-31 (2007) PMID 17680723

Genetic mutations in the LRP5 gene affect Wnt signaling and lead to changes in bone mass in humans. Our in vivo and in vitro results show that activated mutation T253I of LRP5 enhances osteogenesis and inhibits adipogenesis. Inactivating mutation T244M of LRP5 exerts opposite effects.

DOI: 10.1359/jbmr.070721
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