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Force generation of different human cardiac valve interstitial cells: relevance to individual valve function and tissue engineering.

Sally S Smith, Patricia M PM Taylor, Adrian H AH Chester, Sean P SP Allen, Sally A SA Dreger, Mark M Eastwood, and Magdi H MH Yacoub

J Heart Valve Dis 16(4):440-6 (2007) PMID 17702371

Cardiac valves perform highly sophisticated functions that depend upon the specific characteristics of the component interstitial cells (ICs). The ability of valve ICs to contribute to these functions may be related to the generation of different types of tension within the valve structure. The study aim was to characterize cellular morphology and the forces generated by valve ICs and to compare this with morphology and forces generated by other cell types.

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