The present study was conducted to investigate whether the fatty liver phenotype could be helpful in the identification of subgroups with distinct metabolic properties and lipid profiles within familial combined hyperlipidemia (FCHL). One hundred eighty-five FCHL family members participated in the current study; 38 subjects were found to be hypertriglyceridemic, of whom 66% showed evidence of fatty liver as measured with ultrasound. A detailed comparison between the hypertriglyceridemic FCHL subjects with (n = 25) and without (n = 13) fatty liver revealed that, despite very similar plasma triglyceride levels (3.5 vs 3.2 mmol/L in subjects with and without fatty liver, respectively), the fatty liver subgroup presented with significantly higher body mass index, visceral adipose tissue (ultrasound), insulin, and alanine aminotransferase levels. Moreover, very low-density lipoprotein (VLDL) subclass analysis showed that the VLDL2 fraction of the fatty liver subgroup contained significantly less cholesterol and triglycerides (P = .02 for both parameters), which was likely explained by a decreased VLDL2 particle number because VLDL2 apolipoprotein B levels tended to be lower (P = .08). These data indicate that hypertriglyceridemic FCHL subjects may belong to metabolically distinct subgroups and suggest that a refinement of the hypertriglyceridemic FCHL phenotype by adding information on fatty liver will eventually facilitate the elucidation of its complex genetic background.
We present a two-fluid description for iron-based superconductors, which
Contains an itinerant electron Fermi-liquid and a local moment spin-liquid,
Coupled together via an effective Hund's rule interaction. We examine the
Low-energy collective behavior of such a system. We find that an
We introduce efficient online optimization algorithms based on
The alternating direction method (ADM), which can solve online convex
Optimization under linear constraints where the objective could be non-smooth.
We introduce new proof techniques for ADM in the batch setting, which yields a
We present F110W (~J) and F160W (~H) observations of ten submillimeter
Galaxies (SMGs) obtained with the Hubble Space Telescope's (HST's) NICMOS
Camera. Our targets have optical redshifts in the range 2.20<2.81 confirmed
By millimeter CO or mid-IR spectroscopy, guaranteeing that the two bands samp...
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