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Syntheses of immunomodulating androstanes and stigmastanes: Comparison of their TNF-@a inhibitory activity

Javier A JA Ramírez, Andrea C AC Bruttomesso, Flavia M FM Michelini, Sofía L SL Acebedo, Laura E LE Alché, and Lydia R LR Galagovsky

Bioorg Med Chem 15(24):7 (2007) PMID 17892941

Several synthetic stigmastanes and androstane were able to inhibit the TNF-@b production. Some of them were shown to be more potent inhibitors than DHEA.

DOI: 10.1016/j.bmc.2007.09.012
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