Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels.

doi:10.1210/jc.2007-0887

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Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels.

Mattias M Johansson, James D JD McKay, Fredrik F Wiklund, Sabina S Rinaldi, Martijn M Verheus, Carla H CH van Gils, Göran G Hallmans, Katarina K Bälter, Hans-Olov HO Adami, Henrik H Grönberg, Pär P Stattin and Rudolf R Kaaks J Clin Endocrinol Metab 92(12):4820-6 (2007) PMID 17911177

Elevated levels of circulating IGF-I have consistently been associated with increased prostate cancer risk. We recently found a haplotype in the 3' region of the IGF-I gene associated with increased risk of prostate cancer, and we hypothesized that the observed association is mediated by circulating IGF-I.

DOI: 10.1210/jc.2007-0887
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