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Serotonin-1A receptors in frontotemporal dementia compared with controls

Krista L KL Lanctôt, Nathan N Herrmann, Hooman H Ganjavi, Sandra E SE Black, Pablo M PM Rusjan, Sylvain S Houle, and Alan A AA Wilson

Psychiatry Research 156(3):4 (2007) PMID 17976961

Using PET neuroimaging, we demonstrated that four frontotemporal lobar dementia (FTLD) patients had significantly decreased serotonin 5-HT"1"A binding potential (BP) compared with controls in all 10 brain regions examined. These pilot data suggest that profound 5-HT"1"A BP losses may be present and contribute to symptomatology and treatment response in FTLD.

DOI: 10.1016/j.pscychresns.2007.07.003
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