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Effect of oral calcium carbonate on aortic calcification in apolipoprotein E-deficient (apoE-/-) mice with chronic renal failure.

Olivier Phan, Ognen Ivanovski, Igor G Nikolov, Nobuhiko Joki, Julien Maizel, Loïc Louvet, Maud Chasseraud, Thao Nguyen-Khoa, Bernard Lacour, Tilman B Drüeke, and Ziad A Massy

Nephrol Dial Transplant 23(1):82-90 (2008) PMID 17977878

In chronic kidney disease (CKD) patients, the intake of calcium-based phosphate binders is associated with a marked progression of coronary artery and aortic calcification, in contrast to patients receiving calcium-free phosphate binders. The aim of this study was to reexamine the role of calcium carbonate in vascular calcification and to analyse its effect on aortic calcification-related gene expression in chronic renal failure (CRF).

DOI: 10.1093/ndt/gfm699
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